The resultant macular spots or clusters of spots tend to be darker, sometimes almost black.Īmalgam tattoo is the most common subtype of localized argyria and is due to the impregnation of silver-contained dental amalgam into oral mucosa that may occur during restorative dentistry procedures. This color difference becomes evident predominantly in sun-exposed areas.Īzure lunula is a subtype in which there will be a bluish discoloration of the lunula of the fingernails.Ģ. Localized argyria: This is due to local silver deposition through skin incisions or percutaneous absorption via sweat gland pores. Generalized argyria: This is due to systemic exposure to silver followed by its uptake by the dermis, leading to a gray/blue saltish or metallic diffuse hue to the skin. The body tends to store a small amount of natural silver, so the cumulative content of silver increases with age in the body. The accumulated composition is comprised of the binding protein and is present in tissues. With an increased amount of silver, the photoactivation and metal reduction produce a bluish-gray discoloration of the skin in light-exposure areas. Medical uses that that are approved by the FDA are listed below : In modern medicine, silver is utilized in medical-grade forms, including silver sulfadiazine and silver nitrate. Medicinal exposure has become much less common in the modern-day era since the antimicrobial properties of silver are unavailing when compared to today's antibiotics. As a result, there are minimal FDA-approved medicinal uses for products containing silver in the United States. Of note, there have been reported cases of ocular argyrosis in silversmiths due to the deposition of silver in the cornea. Occupational argyria, often transdermal, transmucosal, or inhaled, tends to be more localized to a specific area of the body for instance, the fingers of a jewelry polisher. Jewelers, silver miners, silversmiths, and photograph developers are frequently exposed to compounds containing silver. The most common causes of argyria are secondary to exposures in the workplace or medicinal use. The antimicrobial property of silver is related to the released Ag ions and their ability to interact and irreversibly damage bacterial membranes. The medicinal and health benefits of silver still resonate in the current society because of the oligodynamic effect. Silver spoons, as well as silver pacifiers, were once believed to prevent childhood illnesses. Interestingly, the phrase "born with a silver spoon in his mouth" refers to health instead of wealth. ![]() Silver coins can be found in various economies as a financial currency. Silver has a diverse role in society, from jewelry to filtration devices. It exhibits the highest electrical conductivity, thermal conductivity, and reflectivity of all the metals, giving it a wide array of uses. Silver, in its elemental form, is a precious, white transition metal. Argyria can cause localized or generalized skin pigmentation, depending on the form of silver exposure. The word argyria is derived from the ancient Greek word for silver, argyros. ![]() Argyria is an acquired condition caused by the exposure to or ingestion of silver, and it presents with the insidious onset of gray or blue mucocutaneous discoloration.
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